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pentobarbital will minimize the level or outcome of linagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Use of other therapies is strongly advised when linagliptin is usually to be administered having a CYP3A4 inducerpentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metab